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Information about Tramadol
Tramadol is a man-made analgesic (pain reliever). Its exact work of action is unknown but similar to that of morphine. Like morphine, Tramadol binds to receptors in the brain that are important for transmitting the sensation of pain from throughout the body to. Tramadol, like other narcotics used for the treatment of pain, may be abused. Tramadol is not a nonsteroidal anti-inflammatory drug (NSAID) and does not have the increased risk of stomach ulceration and internal bleeding that can occur with NSAIDs. Tramadol is responsible for reducing the sensation of pain in patients who are afflicted with different kinds of pain.
Storage of Tramadol
Store at room temperature around 15-30 oC (59-86 F).
Dosage of Tramadol
The recommended dose of Tramadol is 50-100 mg every 4-6 hours as needed for pain. The maximum dose is 400 mg/day. To improve tolerance patients should be started at 25 mg/day, and doses may be increased by 25 mg every 3 days to reach 100 mg/day (25 mg 4 times daily). Thereafter, doses can be increased by 50 mg every 3 days to reach 200 mg day (50 mg 4 times daily). Tramadol may be taken with or without food.
Recommended dose for extended release tablets is 100 mg daily which may be increased by 100 mg every 5 days but not to exceed 300 mg /day. Extended release tablets should be swallowed whole and not crushed or chewed.
Drug interactions with Tramadol:
Combining Tramadol with monoamine oxidase inhibitors or selective serotonin inhibitors may result in severe side effects such as seizures or a condition called serotonin syndrome.
Tramadol may increase central nervous system and respiratory depression when combined with alcohol, anesthetics, narcotics, tranquilizers or sedative hypnotics.
Side effects of Tramadol Tramadol is generally well tolerated, and side effects are usually transient. Commonly reported side effects include nausea, constipation, dizziness, headache, drowsiness, and vomiting. Less commonly reported side effects include itching, sweating, dry mouth, diarrhea, rash, visual disturbances, and vertigo. Some patients who received Tramadol have reported seizures. Abrupt withdrawal of Tramadol may result in anxiety, sweating, insomnia, rigors, pain, nausea, diarrhea, tremors, and hallucinations.
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